The squalestatins, novel inhibitors of squalene synthase produced by a species of Phoma. IV. Preparation of fluorinated squalestatins by directed biosynthesis.

نویسندگان

  • R J Cannell
  • M J Dawson
  • R S Hale
  • R M Hall
  • D Noble
  • S Lynn
  • N L Taylor
چکیده

Feeding of fluorinated benzoic acids to fermentations of a Phoma sp. resulted in the biosynthesis of a series of novel fluorinated squalestatins. The feeding studies, isolation, structural elucidation and biological activities of these compounds are reported.

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The squalestatins, novel inhibitors of squalene synthase produced by a species of Phoma. III. Biosynthesis.

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عنوان ژورنال:
  • The Journal of antibiotics

دوره 46 9  شماره 

صفحات  -

تاریخ انتشار 1993